Developed API’s : NSAID

CelecoxibEtoricoxib


Celecoxib

CAS NO. 169590-42-5
Therapeutic Class: Selective Non-steroidal Anti inflammatory drug (NSAID)
Pharmacopoeia compliance: USP/Ph.Eur

Celecoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain in adults, painful menstruation and juvenile rheumatoid arthritis in people two years or older.

A highly selective reversible inhibitor of the COX-2 isoform of cyclooxygenase, celecoxib inhibits the transformation of arachidonic acid to prostaglandin precursors. Therefore it has antipyretic, analgesic, anti-inflammatory properties.

 


Etoricoxib

CAS NO. 202409-33-4
Therapeutic Class: Anti-inflammatory, analgesic
Pharmacopoeia compliance: USP/Ph.Eur

Etoricoxib is indicated for the treatment of rheumatoid arthritis, psoriatic, arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Approved indications differ by country.

Selective COX-2 inhibitors show less activity on COX-1 compared to traditional non-steroidal anti-inflammatory drugs (NSAID). This reduced activity is the cause of reduced gastrointestinal side effects, as demonstrated in several large clinical trials performed with different coxibs.